In which of the following situations, a poor increment in platelet count is expected after platelet transfusion?
A- Previous splenectomy
B- A patient with liver transplantation
C- Thin and short patient
D- Corticosteroid use
E - Aspirin use
Check the answer and explanation, below
Answer : B
Splencetomy is associated with thrombocytosis. Hyperspleneism is associated with thrombocytopenia and less favorable response to platelet transfusion.
Organ transplanatation in general is associated with p[latelet alloimmunization and week response to platelet transfusion, usually by formation of antibodies directed against HLA antigens.
Other causes of alloimmunization are previous transfusions, pregnancy, and organ transplantation.
Corticosteroids can improve response to platelet transfusion in patients with immune thrombocytopenia.
Aspirin impairs platelet aggregation and doesn't affect platelet count.